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FET/Frozen Embryo Transfer

Acupuncture for frozen embryo transfer
You'll start preparation for frozen embryo treatment before the cycle where the patient plans to transfer. If the patient has poor uterine blood flow via a doppler test (test available at CCRM,) then you can request to. modify the plan. In the case of uterine blood flow impedient, treatment is bi-weekly for five weeks before transfer. If you suspect you may have poor uterine blood flow, but have not got access to the test, there are other protocols available, as published by CCRM.
FET/Frozen Embryo Transfer
Treatment is 4 to 6 sessions in the course of a month, ideally beginning 3 to 4 cycles before frozen transfer. On transfer day, treatment is before and after transfer.

  • -Patients who had frozen embryos from a previous IVF cycle.
    -Patients who have had issues at a previous transfer such as thin uterine lining.
    -Pre-genetically tested frozen embryo transfer.
    -Donor embryo.

    Patients who are requesting supportive care towards having a frozen transfer are encouraged to start preparatory treatment three cycles prior to transfer, ideally.

    At very absolute minimum, the treatment cycle for FET may commence the cycle BEFORE the planned transfer. The month before transfer is the ideal time to recheck many of the basic vitamin levels which correspond to healthy pregnancy, in addition to other hormonal aspects that exert a profound impact on the probability of successful implantation.

    The quality and integrity of the uterine lining is also a critical factor of successful implantation. In scientific studies like those below, treatment is started three cycles before transfer. In my clinical experience, I rarely see patients begin treatment with a three cycle lead time; one to two cycles pre-transfer are typically sufficient.

  • Electrostimulation on acupuncture points leading to the IVF transfer improves the quality and receptivity of the uterine lining.

    A study published in the latest issue of peer-reviewed British Medical Journal (Acupuncture in Medicine) found the rates of embryo implantation, clinical pregnancy, and live birth rates were higher in patients who received acupuncture leading to the transfer.

    They also found significant measurable changes in the endometrium (uterine lining):

    • Acupuncture improved the chances of triple-line pattern endometrial lining. It has been shown in studies that triple-line pattern is associated with good IVF outcome.
    • Endometrial perfusion (blood supply to the uterine lining) is an important factor in the process of implantation. The study found greater endometrial and subendometrial vascularisation following a series of acupuncture treatments leading to embryo transfer.
    • Acupuncture improved HOXA10 expression. Higher HOXA10 is associated with greater endometrial receptivity and good pregnancy outcomes. HOXA10 expression is lower in the uteri of women with hydrosalpinx, PCOS, and endometriosis.

  • Frequency of Treatment Utilizing Acupuncture to Improve Endometrial Receptivity

    Women in this study had six acupuncture sessions per cycle for three menstrual cycles. See the abstract of the study below.

  • Acupunct Med doi:10.1136/acupmed-2014-010572 Original paper
    Zhenhong Shuai1, Fang Lian2, Pengfei Li3, Wenxiu Yang2 + Author Affiliations
    1Shandong University of Traditional Chinese Medicine, Jinan, China
    2Integrative Medicine Research Centre of Reproduction and Heredity, the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China
    3Department of Urology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Correspondence to Professor Fang Lian, Integrative Medicine Research Centre of Reproduction and Heredity, the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, No 42 Wen Hua Xi Road, Jinan 250011, China;
    Received 1 April 2014
    Revised 12 September 2014
    Accepted 20 September 2014
    Published Online First 10 October 2014

  • Objective: To evaluate the effect of Electrical Stimulation with Acupuncture on endometrial HOXA10 protein expression and three-dimensional (3D) power Doppler ultrasound parameters as markers of endometrial receptivity in women undergoing frozen-thawed embryo transfer (FET).

    Methods: A total of 68 women undergoing FET were randomised to receive Electrical Stimulation with Acupuncture or acupuncture points CV3, CV4 and SP6 and Zigong bilaterally. Both groups had six sessions per cycle for three menstrual cycles prior to the scheduled FET. Each session lasted 30 mins and was repeated every other day. 3D power Doppler ultrasound parameters, HOXA10 protein expression and rates of embryo implantation, clinical pregnancy and live birth were compared.

    Results: There were no significant differences between the two groups in endometrial thickness or endometrial volume. The ultrasonographic endometrial triple-line pattern was present more often in theranscutaneous electrical acupuncture point stimulation group (p=0.002). The Electrical Stimulation with Acupuncture group had a greater endometrial and subendometrial vascularisation index (VI) than the mock Electrical Stimulation with Acupuncture group (p=0.001 and p

    Trial registration number ChiCTR-TRC-14004448.

    Acupuncture has significant effect on chances of success with Frozen Embryo TransferIVF patients.